The importance of the production of phosphatidic acid for the release of arachidonic acid in stimulated platelets
- 1 June 1981
- journal article
- Published by Springer Nature in Inflammation Research
- Vol. 11 (6-7), 536-537
- https://doi.org/10.1007/bf01978728
Abstract
Phosphatidic acid is formed by platelets as a result of the combined activities of phospholipase C and diacylglycerol kinase. The initial thrombin-activated phospholipase C-mediated reaction is quinacrine insensitive and is followed by quinacrine-sensitive phospholipase A2 activities. The phosphatidic acid released probably results in cellular calcium gating, which among other actions, might release arachidonic acid by activating phospholipases A2: Indeed, we have detected a phosphatidic acid-specific phospholipase A2 in platelets, which might have an important role in the liberation of arachidonic acid.Keywords
This publication has 9 references indexed in Scilit:
- The phosphatidylinositol cycle and the regulation of arachidonic acid productionNature, 1981
- Phospholipase A2 activity specific for phosphatidic acid. A possible mechanism for the production of arachidonic acid in platelets.Journal of Biological Chemistry, 1981
- The initial action of thrombin on platelets. Conversion of phosphatidylinositol to phosphatidic acid preceding the production of arachidonic acid.Journal of Biological Chemistry, 1981
- Phospholipase A2 and phospholipase C activities of platelets. Differential substrate specificity, Ca2+ requirement, pH dependence, and cellular localization.Journal of Biological Chemistry, 1980
- Serine esterase inhibitors block stimulus-induced mobilization of arachidonic acid and phosphatidylinositide-specific phospholipase C activity in platelets.Journal of Biological Chemistry, 1980
- Phospholipid Metabolism in Stimulated Human PlateletsJCI Insight, 1980
- Transfer of arachidonic acid between phospholipids in rat liver microsomesBiochemical and Biophysical Research Communications, 1979
- Diglyceride lipase: a pathway for arachidonate release from human platelets.Proceedings of the National Academy of Sciences, 1979
- Stimulation of phosphatidic acid production in platelets precedes the formation of arachidonate and parallels the release of serotoninBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1979