Cardiovascular effects of positive-pressure ventilation in normal subjects
- 1 August 1979
- journal article
- research article
- Published by American Physiological Society in Journal of Applied Physiology
- Vol. 47 (2), 453-461
- https://doi.org/10.1152/jappl.1979.47.2.453
Abstract
In normal subjects during 15-min positive-pressure ventilation with 10 cmH2O end-expiratory pressure (PEEP), cardiac output fell 19% due to a fall in stroke volume. Transmural mean right atrial pressure rose 3.1 cmH2O and right ventricular end-diastolic diameter increased 15%. Simultaneously, left ventricular end-diastolic diameter decreased 21%, ejection time increased 11%, and velocity of circumferential fiber shortening fell 30%. Right ventricular filling increased and left ventricular filling decreased. The function of the right ventricle was impaired and the function of the left ventricle may have been impaired. Cardiac output gradually increased due to a 7% increase in heart rate as PEEP was continued for 1 h and transmural mean right atrial pressure also increased further by 2.4 cmH2O. Compensation for the reduced stroke volume occurred as filling pressures and heart rate rose, but ventricular function remained impaired for the entire duration of PEEP. On resuming spontaneous breathing, cardiac output and ventricular function returned to base-line levels. The reduced cardiac output during PEEP is apparently not due to a direct mechanical reduction in right ventricular filling.This publication has 2 references indexed in Scilit:
- AN ANALYSIS OF FACTORS AFFECTING THE MEASUREMENT OF PULMONARY DIFFUSING CAPACITY BY THE SINGLE BREATH METHOD*Journal of Clinical Investigation, 1961
- POSITIVE PRESSURE RESPIRATION AND ITS APPLICATION TO THE TREATMENT OF ACUTE PULMONARY EDEMAAnnals of Internal Medicine, 1938