AMINO ACID TOLERANCE TESTS IN CHILDREN

Abstract

THIS study was undertaken to determine the rate of absorption of protein, partially hydrolyzed protein, and amino acids in patients with cystic fibrosis of the pancreas, the celiac syndrome and other conditions. The disease known as cystic fibrosis of the pancreas has been separated from that group of symptoms commonly referred to as the "celiac syndrome." Siwe¹ first suggested in 1932 that the pancreatic secretions in cystic fibrosis of the pancreas are deficient in trypsin. Andersen² noticed the presence of essentially normal levels of trypsin in the duodenal juice in patients with the celiac syndrome. It has, therefore, become the custom to establish the diagnosis of cystic fibrosis of the pancreas by passage of a tube into the duodenum, aspiration of the duodenal contents and demonstration of the absence of trypsin in the duodenal fluid. The finding of an adequate level of trypsin in the aspirated secretions is