L3T4+ T lymphocytes play a major role in the pathogenesis of murine cerebral malaria.
Open Access
- 1 October 1986
- journal article
- research article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 137 (7), 2348-2354
- https://doi.org/10.4049/jimmunol.137.7.2348
Abstract
The pathogenic importance of L3T4+ T cells in the development of murine cerebral malaria was demonstrated by the following observations. First, in vivo administration of an anti-L3T4 monoclonal antibody protected Plasmodium berghei-infected CBA mice from the development of neurologic symptoms and acute death. In contrast, injection with an MAb directed against the Ly.2+ T cell subset had no protective effect. Second, thymectomized, irradiated, and bone marrow reconstituted (ATxBM) CBA mice did not develop acute cerebral malaria when infected by P. berghei, although parasitemia and anemia rose to the same extent as in normal P. berghei-infected CBA mice. The occurrence of lethal neurologic perturbations could be restored in ATxBM mice selectively reconstituted with L3T4+ Ly.2-lymphocytes but not with Ly.2+ L3T4- cells. Third, adoptive transfer of L3T4+ cells from mice dying of cerebral malaria into euthymic mice subsequently infected by P. berghei led to an acceleration of the disease. These results confirm that cerebral malaria in mice is the expression of immunopathologic reactions and outline the particular pathogenic importance of L3T4+ T cells.This publication has 23 references indexed in Scilit:
- IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement.The Journal of Immunology, 1980
- IMMUNOPATHOLOGICAL ASPECTS OF PLASMODIUM-BERGHEI INFECTION IN 5 STRAINS OF MICE .2. IMMUNOPATHOLOGY OF CEREBRAL AND OTHER TISSUE LESIONS DURING THE INFECTION1980
- IMMUNOPATHOLOGICAL ASPECTS OF PLASMODIUM-BERGHEI INFECTION IN 5 STRAINS OF MICE .1. IMMUNE-COMPLEXES AND OTHER SEROLOGICAL FEATURES DURING THE INFECTION1980
- Cerebral malaria in the United Kingdom.Journal of Clinical Pathology, 1979
- IgM Rheumatoid Factors in Mice Injected with Bacterial LipopolysaccharidesThe Journal of Immunology, 1979
- Cerebral MalariaArchives of Neurology, 1978
- Diet and cerebral malaria: the effect of famine and refeedingThe American Journal of Clinical Nutrition, 1978
- IMMUNOLOGICAL RESPONSE OF CBA MICE TO P-YOELII .1. GENERAL CHARACTERISTICS, EFFECTS OF T-CELL DEPRIVATION AND RECONSTITUTION WITH THYMUS GRAFTS1977
- ROUTINE ASSAY FOR DETECTION OF IMMUNE-COMPLEXES OF KNOWN IMMUNOGLOBULIN CLASS USING SOLID-PHASE CLQ1976
- HISTOPATHOLOGIC CHANGES IN CEREBRAL MALARIA AND THEIR RELATION TO PSYCHOTIC SEQUELSArchives of Neurology & Psychiatry, 1946