Conformation of Blood-Group and Virus Receptor Glycoproteins from Red Cells and Secretions
- 18 October 1968
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 162 (3851), 365-367
- https://doi.org/10.1126/science.162.3851.365
Abstract
Optical rotatory dispersion of human blood-group and virus receptor glycoproteins from erythrocytes and secretions was studied in the far-ultraviolet. Erythrocyte membrane blood-group glycoproteins, with potent virus receptor activities, contained significant alpha-helical and extended beta conformations, whereas the glycoproteins of secretions were largely disordered. These conclusions were supported by determination of the Moffitt constants (b0) and by measurements of circular dichroism.Keywords
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