Membranes in Polyribosome Formation by Rabbit Reticulocytes
- 21 July 1967
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 157 (3786), 323-325
- https://doi.org/10.1126/science.157.3786.323
Abstract
When rabbit reticulocytes are incubated with n-butanol, an agent disruptive to the structure and function of cellular membranes, there is a rapid disaggregation of the polyribosomes. Reaggregation is promoted when the n-butanol is diluted below a critical concentration or when the cells are washed free of the alcohol and the incubation is continued. Neither disaggregation nor regeneration will occur in the absence of protein synthesis. These observations suggest that integrity of the reticulocyte membrane is necessary for the attachment of ribosomes to messenger RNA and for the formation of polyribosomes.This publication has 34 references indexed in Scilit:
- Effects of cycloheximide on polyribosome function in reticulocytesJournal of Molecular Biology, 1967
- Tryptophan Deficiency in Rabbit Reticulocytes: Polyribosomes during Interrupted Growth of Hemoglobin ChainsScience, 1967
- The mechanism of sodium fluoride and cycloheximide inhibition of hemoglobin biosynthesis in the cell-free reticulocyte systemJournal of Molecular Biology, 1966
- Polyribosomes and control of protein synthesis: Effects of sodium fluoride and temperature in reticulocytesJournal of Molecular Biology, 1966
- Inhibition of protein synthesis by cycloheximide in rabbit reticulocytesBiochemical and Biophysical Research Communications, 1965
- Effects of Lower Aliphatic Alcohols on Mitochondrial Structure.Acta Chemica Scandinavica, 1965
- Initiation of hæmoglobin synthesis in cell-free systemsJournal of Molecular Biology, 1964
- Ribosomal Aggregates Engaged in Protein Synthesis : Ergosome Breakdown and Messenger Ribonucleic Acid TransportNature, 1963
- Potassium and sodium exchanges in rabbit red cells treated with n‐butyl alcoholJournal of Cellular and Comparative Physiology, 1951
- A relation between the permeability of the red cell and its metabolismTransactions of the Faraday Society, 1937