Dependence of manganese turnover on intake

Abstract

The turnover of parenterally administered Mn54 was found to be directly related to the level of stable Mn in the diet of mice over a wide range. The concentration of Mn54 in various tissues was also directly related to the level of Mn55 in the diet, suggesting that a variable excretion rather than a variable absorption regulates the concentration of this metal in tissues. The whole-body turnover of Mn54 can be approximated roughly by 2 exponential functions suggesting that Mn is distributed in at least 2 sets of compartments with different sizes and transfer constants. The relative size and transfer constant of the compartment with the slower turnover was linearly related to the concentration of manganese in the diet.