The use of acetylethyleneimine in the production of inactivated foot-and-mouth disease vaccines
- 1 September 1963
- journal article
- research article
- Published by Cambridge University Press (CUP) in Epidemiology and Infection
- Vol. 61 (3), 337-344
- https://doi.org/10.1017/s0022172400039620
Abstract
Suspensions of FMD virus treated with 0·05% formalin at 26° C. for periods up to 144 hr. remained infective for cattle, although the infectivity could not be detected in the presence of aluminium hydroxide. Infectivity was detected in similar virus suspensions which had been treated with 0·05% AEI at 37° C. for 8 hr. but not in suspensions treated for 12 hr.Vaccines prepared from these suspensions were antigenically potent and serum neutralization tests demonstrated the development and regression of serum antibody. The AEI vaccines were at least as potent as the corresponding formalin vaccines.Keywords
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