Clinical Studies on the Cardiac Performance by Means of Transseptal Left Heart Catheterization

Abstract

In the resting state of 6 cases of hyperthyroidism and 2 cases of anemia, and before and after infusion of 6% polyvinylpyrrolidone (PVP) 5 mg/kg body weight in 3 normal and 3 hypertensive cases, the left ventricular performance was studied by the transseptal left heart catheterization using radioisotope dilution method and compared with those of normal and low output failure. Thus following results were obtained. In hyperthyroidism, with the increase of heart rate, stroke volume was increased, which may be caused by the acceleration of left ventricular function shown by the change of circumferential shortening rate (CSR) and mean systolic ejection rate (MSER), and by the increase of blood inflow shown by increase of left ventricular end-diastolic volume (LVEDV). The high output state in induced hypervolemia is due to the increase of blood inflow, but the left ventricular function is rather depressed. Thyrotoxic heart is not only accelerated by thyroid hormone but also overloaded by increased venous return.