Analogs of Glutamic Acid: Synthesis and Biological Evaluation
- 1 September 1990
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 20 (17), 2667-2673
- https://doi.org/10.1080/00397919008051475
Abstract
The reaction of bromodiester 6 with base in liquid ammonia affords good yields of aminocyclopropane diesters 8 and 9. The corresponding diacids were not inhibitors of AAT.Keywords
This publication has 10 references indexed in Scilit:
- Stereochemical studies on the reactions catalyzed by the PLP-dependent enzyme 1-aminocyclopropane-1-carboxylate deaminaseJournal of the American Chemical Society, 1984
- A synthesis of geminally functionalized heterocyclic aminocarboxylic acids by cycloaddition of ethyl N-acetyl-α,β-dehydroalaninate with 1,3-dipolesTetrahedron Letters, 1983
- Synthesis of 1-azidocyclopropanecarboxylates from 2-azido-2alkenoatesTetrahedron Letters, 1982
- Suicide substrates: mechanism-based enzyme inactivatorsTetrahedron, 1982
- On the stereochemistry of coronatine : revised absolute configuration of (+)-coronamic acidTetrahedron Letters, 1979
- Electrophilic cyclopropanes in organic synthesisAccounts of Chemical Research, 1979
- Ethylene biosynthesis: Identification of 1-aminocyclopropane-1-carboxylic acid as an intermediate in the conversion of methionine to ethyleneProceedings of the National Academy of Sciences, 1979
- [79] Pyridoxal 5′-phosphate and analogs as probes of coenzyme-protein interactionMethods in Enzymology, 1979
- Strained ring systems. XII. Synthesis of several dimethyl .DELTA.1-cycloalkene-1,2-dicarboxylates and certain 4-substituted bicyclo[2.1.0]pentane-1-carboxylic acidsThe Journal of Organic Chemistry, 1972
- Nucleophilic Ring-Opening Additions to 1,1-Disubstituted CyclopropanesThe Journal of Organic Chemistry, 1965