Influence of Adrenergic Blockade and an Amine Oxidase Inhibitor on Reserpine Hypotension

Abstract

In proper doses, administration of reserpine phosphate subsequent to adrenergic blockade with phentolamine will produce a more rapid decline in blood pressure than is commonly obtained by administration of reserpine alone. After pretreatment with amine oxidase inhibitor, choline p-tolyl ether, reserpine will produce pressor responses. Data are interpreted as supporting the hypothesis that reserpine releases sympathomimetic humoral agents which mask the early onset of the cardiovascular actions commonly attributed to reserpine.