Absorption and Excretion of Four Penicillins

Abstract

THE first of the semisynthetic penicillins to be prepared and exploited for clinical use after the isolation of pure 6-aminopenicillanic acid from penicillin fermentations¹ is the potassium salt of the mixture of the D and L isomers of 6-(alpha-phenoxypropionamido) penicillanate or phenoxyethyl penicillin, also designated BRL152² or P152DL³ and now given the generic name phenethicillin.§ On the basis of observations made by the manufacturers and some of their collaborators,^{2 , 4 , 5} one of the major advantages claimed for this new form of penicillin, and featured in all the advertisements of this product, is that molecular-equivalent doses for oral administration produce serum concentrations . . .