A theoretical study of the structure of parathyroid hormone.

Abstract

Theoretical analysis of the tertiary and secondary structure of parathyroid hormone was conducted. By combining interpretations from this analysis with chemical data available in the literature, certain structural features of the hormone are consistently predicted. The proposed model for the hormone contains 2 domains dominated by hydrophobic clustering of critical residues within each domain and separated by an exposed linker region. In the prediction of 2 domains with a linker region, the model is similar to that proposed by Fiskin et al., but it differs significantly in other respects. The proposed structural features are apparent in the bovine, human and procine species of hormone.