Alcohol Preference in the Rat: Reduction Following Depletion of Brain Serotonin
- 28 June 1968
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 160 (3835), 1469-1471
- https://doi.org/10.1126/science.160.3835.1469
Abstract
Preference for ethyl alcohol was significantly reduced or totally abolished in rats given orally p-chlorophenylalanine, a tryptophan hydroxylase inhibitor that selectively depletes brain serotonin. Some aversion to alcohol was observed while p-chlorophenylalanine was administered, but the rats' rejection of alcohol was even more marked after the drug was discontinued. Oral administration of α-methyl-p-tyrosine, a tyrosine hydroxylase inhibitor that depletes brain catecholamines, slightly reduced selection of alcohol, but preference returned to normal as soon as α-methyl-p-tyrosine was terminated.Keywords
This publication has 14 references indexed in Scilit:
- Voluntary Alcohol Consumption in Animals: Peripheral and Intracerebral FactorsPsychosomatic Medicine, 1966
- A procedure for eliminating position habit in preference-aversion tests for ethanol and other fluidsPsychonomic Science, 1966
- Chemical Coding of Behavior in the BrainScience, 1965
- ITEM ANALYSIS AND TEST RELIABILITYETS Research Bulletin Series, 1964
- Measurement of alcohol preference in genetic experiments.Journal of Comparative and Physiological Psychology, 1964
- Inhibition of the hydroxylation of tryptophan and phenylalanine by α-methyl-dopa and similar compoundsLife Sciences, 1964
- Alcohol Consumption in Rats: Effects of Intracranial Injections of EthanolScience, 1963
- Cholinergic Tracing of a Central Neural Circuit Underlying the Thirst DriveScience, 1962
- Monoamine Oxidase Inhibition by Ethanol in vitroNature, 1962
- Depression of Serotonin and Norepinephrine Levels in Brain Stem of Rabbit by Ethanol.Experimental Biology and Medicine, 1960