A Study of Adrenaline-Dansyl Derivatives for Separation by Liquid Chromatography. Application to Blood Plasma Analysis
- 1 January 1978
- journal article
- research article
- Published by Taylor & Francis in Journal of Liquid Chromatography
- Vol. 1 (4), 443-455
- https://doi.org/10.1080/01483917808060010
Abstract
A plausible mechanism and explanation for the instability of the tri-dans adrenaline has been given. The formation of dimeres accompanied by the loss of one dansyl moiety per adrenaline molecule seems to take place upon U.V. irradiation. This is followed by an increase in fluorescence due to release of strain (steric hindrance) on the molecule. The feasibility of the pre-column dansylation. technique for the analysis of adrenaline and noradrenaline in plasma samples has been demonstrated. Taking necessary precautions, quantitation in the low nonagram region is possible with a reproducibilityThis publication has 10 references indexed in Scilit:
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