Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum
- 1 October 1982
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 299 (5885), 691-698
- https://doi.org/10.1038/299691a0
Abstract
In addition to its previously characterized, six different polypeptide components, signal recognition protein—which functions in protein translocation across and integration into the endoplasmic reticulum membrane—contains a 7S RNA molecule. The RNA is closely identified with the small cytoplasmic 7SL RNA and is required for both structural and functional properties of signal recognition protein—which we therefore rename signal recognition particle.Keywords
This publication has 37 references indexed in Scilit:
- Secretory protein translocation across membranes—the role of the ‘docking protein’Nature, 1982
- SnRNAs, SnRNPs, and RNA ProcessingAnnual Review of Biochemistry, 1982
- Signal recognition protein is required for the integration of acetylcholine receptor delta subunit, a transmembrane glycoprotein, into the endoplasmic reticulum membrane.The Journal of cell biology, 1982
- Synthesis in vitro and Translocation of Apolipoprotein AI across Microsomal VesiclesEuropean Journal of Biochemistry, 1981
- Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein.The Journal of cell biology, 1981
- Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes.The Journal of cell biology, 1981
- Translocation of proteins across the endoplasmic reticulum. II. Signal recognition protein (SRP) mediates the selective binding to microsomal membranes of in-vitro-assembled polysomes synthesizing secretory protein.The Journal of cell biology, 1981
- Purification of a membrane-associated protein complex required for protein translocation across the endoplasmic reticulum.Proceedings of the National Academy of Sciences, 1980
- Protein transfer across microsomal membranes reassembled from separated membrane componentsNature, 1978
- The 7S RNA Common to Oncornaviruses and Normal Cells is Associated with PolyribosomesProceedings of the National Academy of Sciences, 1974