Enkephalin Inhibits Presynaptically the Contractility of Urinary Tract Smooth Muscle
- 1 January 1987
- journal article
- research article
- Published by Wiley in British Journal of Urology
- Vol. 59 (1), 31-35
- https://doi.org/10.1111/j.1464-410x.1987.tb04574.x
Abstract
The influence of methionine-enkephalin and leucine-enkephalin on human detrusor and on pig detrusor, trigone, bladder neck and urethral smooth muscle was investigated in vitro. The enkephalins inhibited the smooth muscle contractility presynaptically. Methionine-enkephalin was about 40% more potent than leucine-enkephalin. Phentolamine-resistant contractions were less inhibited by the enkephalins than atropine-resistant contractions and contractions that were not blocked. The inhibitory nerve responses of the trigone, bladder neck and urethra were unaffected.This publication has 27 references indexed in Scilit:
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