RATE OF DISAPPEARANCE OF GROWTH HORMONE FROM THE PLASMA OF RATS AFTER A SINGLE INTRAVENOUS INJECTION
- 1 June 1955
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 19 (2), 181-184
- https://doi.org/10.1530/acta.0.0190181
Abstract
The fall in concentration of the hormone was determined by injecting lyophilized samples of the plasma into hypophysectomized rats, and using the tibial epiphyseal cartilage width assay. The concentration of the injected growth hormone fell exponentially as a function of time with a biological half life of 40 minutes. By extrapolation to zero time, it was estimated that only about 1B of the injected dose could be found in the plasma immediately after injection.Keywords
This publication has 2 references indexed in Scilit:
- SURVIVAL IN THE CIRCULATION OF THE GROWTH AND ADRENOCORTICOTROPHIC HORMONES AS EVIDENCED BY PARABIOSISAmerican Journal of Physiology-Legacy Content, 1950
- BIOASSAY OF THE PITUITARY GROWTH HORMONE. WIDTH OF THE PROXIMAL EPIPHYSIAL CARTILAE OF THE TIBIA IN HYPOPHYSECTOMI2ED RATS1,2Endocrinology, 1943