The Effect of Sulfanilamide on Salt and Water Excretion in Congestive Heart Failure

Abstract

THE importance of the sodium ion in edema is well recognized. If a specific method were available for producing selective inhibition of the renal tubular reabsorption of sodium from the glomerular filtrate, it might well prove useful in the study and treatment of edema. A possible method is suggested by the studies of Pitts and Alexander.¹ Under the conditions of their experiments they demonstrated that the renal tubules must make an active addition of acid to the glomerular filtrate to account for the acidity of the urine. The only source of acid large enough to account for the acidification of . . .