Oral hairy leukoplakia: observations in 95 cases and review of the literature
- 1 August 1989
- journal article
- review article
- Published by Wiley in Journal of Oral Pathology & Medicine
- Vol. 18 (7), 410-415
- https://doi.org/10.1111/j.1600-0714.1989.tb01573.x
Abstract
Oral hairy leukoplaskia (HL) was observed in 25.4% of 373 HIV-seropositive patients (n = 95). 87 were men of an average age of 37.1 yr, 8 were women (30.3 yr). 71.6% of the patients were male homosexuals. At initial diagnosis of HL the majority of cases was classified as CDC IVc1 (45.3%) and CDC II (22.1%). Average CD4/CD8 ratio (n = 19) was 0.24 with a range of 0.04-1.0. Thirty biopsies of HL revealed some of the histologic features thought to be characteristic. In only 20 of 30 biopsies EB-virus-specific-capsid antigen was detected. The problems of clinical and histological diagnosis of HL are discussed. Further strict criteria are necessary in order to define HL more distinctly.Keywords
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