A-16686, a new antibiotic from Actinoplanes I. Fermentation, isolation and preliminary physico-chemical characteristics.

Abstract

Actinoplanes sp. ATCC 33076 (a new strain) produced an antibiotic, designated A-16686, which was a complex of 3 closely-related polypeptides containing chlorinated phenyl moieties and D-mannose. The complex and the single fractions possessed good activity against gram-positive bacteria. A-16686 specifically inhibited synthesis of the bacterial cell wall.