Reaction of antipolynucleotide antibody from systemic lupus erythematosus patient serum with double‐stranded DNA complexed to protein
- 1 July 1987
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 30 (7), 814-818
- https://doi.org/10.1002/art.1780300712
Abstract
Antipolynucleotide antibody from systemic lupus erythematosus patient serum was found to interact with common determinants of double-stranded DNA (dsDNA) complexed to protein within nucleosomes, and with protein-free denatured DNA. In contrast, purified dsDNA isolated from nucleosomes manifested decreased reactivity with antipolynucleotide antibody. These data suggest that immunoassays using denatured DNA antigen substrate are useful for identifying a broad spectrum of antipolynucleotide antibodies that are reactive with dsDNA complexed to protein.This publication has 13 references indexed in Scilit:
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