NEUTRAL STEROID SULPHATION AND OESTROGEN BIOSYNTHESIS IN VITRO BY A FEMINIZING LEYDIG CELL TUMOUR OF THE TESTIS
- 1 August 1966
- journal article
- research article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 35 (4), 409-417
- https://doi.org/10.1677/joe.0.0350409
Abstract
SUMMARY: The metabolism of [7α-3H]pregnenolone and [4-14C]dehydroepiandrosterone by a feminizing Leydig cell tumour from a man has been studied in vitro. The tumour formed the 3β-sulphoxy derivatives of pregnenolone, 17α-hydropregnenolone and dehydroepiandrosterone. Carbon-labelled oestradiol-17β and tritiated oestriol were isolated from the tumour indicating that the probable pathway of the formation of oestriol was by way of 16α-hydroxylated steroids not involving DHA or oestradiol.This publication has 18 references indexed in Scilit:
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