Overexpression of caveolin-1 and -2 in cell lines and in human samples of inflammatory breast cancer
- 22 October 2005
- journal article
- research article
- Published by Springer Nature in Breast Cancer Research and Treatment
- Vol. 95 (3), 219-228
- https://doi.org/10.1007/s10549-005-9002-1
Abstract
Inflammatory breast cancer (IBC) is the most aggressive form of locally advanced breast cancer (LABC). The IBC phenotype is characterized by an infiltrative growth pattern, increased (lymph)angiogenesis and the propensity to invade dermal lymphatics. In pancreatic cancer, interactions between caveolin-1 and RhoC GTPase, a key molecule in causing the IBC phenotype, regulate tumour cell motility and invasion. In this study we sought to investigate the role of caveolin-1 and -2 in IBC cell lines and in human IBC samples.Keywords
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