Intestinal excretion of hexachlorobenzene

Abstract

1. The intestinal excretion of hexachlorobenzene (HCB) was studied in rats using the method of pendular perfusion. One and four weeks after i.p. application of 100 mg HCB/kg body weight segments of jejunum, ileum and colon were perfused with light liquid paraffin or squalane for 5 h. 2. The highest amount of HCB was excreted into jejunum, followed by ileum and colon. After 5 h HCB concentration in jejunal perfusion medium equals that in plasma. 3. Serosal tissue of intestinal segments contained higher HCB concentrations as compared to mucosa. 4. Paraffin treatment decreased the HCB content in both serosal and mucosal tissue of jejunum and ileum but not of colon.