An SHV-Derived Extended-Spectrum β-Lactamase in Pseudomonas aeruginosa
- 1 May 1999
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 43 (5), 1281-1284
- https://doi.org/10.1128/aac.43.5.1281
Abstract
A clinical isolate of Pseudomonas aeruginosa RP-1 produced the extended-spectrum β-lactamase (ESBL) SHV-2a. Its gene was expressed from a composite promoter made of the −35 region derived from the left inverted repeat of IS 26 and the −10 region from the bla SHV-2a promoter itself. The DNA sequences immediately surrounding bla SHV-2a were homologous to plasmid pMPA2a from Klebsiella pneumoniae KpZU-3, while further away and 3′ to the bla SHV-2a gene, a sequence corresponding to the left end of Tn 1721 was detected, thus indicating a likely enterobacterial origin of this ESBL gene.Keywords
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