Lack of G2019S LRRK2 mutation in a cohort of Taiwanese with sporadic Parkinson's disease

Abstract

Mutations in the leucine‐rich repeat kinase 2 (LRRK2) gene have been shown to cause autosomal dominant and sporadic Parkinson's disease (PD). We report here the frequency of a common heterozygous mutation, 2877510G>A, which produces a glycine‐to‐serine amino acid substitution at codon 2019 in idiopathic Taiwanese PD. The extreme rarity of the G2019S mutation in our population suggests the occurrence of this mutation resulted from a common European founder. © 2006 Movement Disorder Society