Defective Serotonin (5-HT) Transport Mechanism in Platelets from Patients with Endogenous and Allergic Asthma
- 1 January 1982
- Vol. 37 (1), 29-39
- https://doi.org/10.1111/j.1398-9995.1982.tb04114.x
Abstract
5-HT (serotonin) uptake by platelets from patients with asthma was studied. In patients with symptomatic endogenous asthma, 5-HT uptake by platelets was severely impaired, and slightly disturbed in platelets from patients with asymptomatic exogenous asthma. Serum and whole blood from asthmatic patients contained higher amounts of 5-HT than that of normal subjects and elevated levels of 5-HT-metabolites such as kynurenine were demonstrated in such patients. Tryptophan load on asthmatics leads to abnormally high urinary excretion of xanthurenic acid. Since tryptophan is the main precursor in 5-HT synthesis, a reduced tryptophan intake might be of importance.Keywords
This publication has 13 references indexed in Scilit:
- The effect of various inhibitors on the 5-ht binding and uptake by human plateletsThrombosis Research, 1981
- The 5-hydroxytryptamine take-up mechanism in normal platelets and platelets from migraine and asthmatic patientsThrombosis Research, 1980
- Inhibition of 5-hydroxytryptamine uptake in human platelets by antidepressant agents in vivoPsychopharmacology, 1980
- Approaches to Brain Amines in Psychiatric Patients: A Reevaluation of Cerebrospinal Fluid StudiesPublished by Springer Nature ,1978
- Serum IgE levels in healthy children quantified by a sandwich technique (PRIST*)Clinical and Experimental Allergy, 1976
- Specific IgE determination by RAST compared with skin and provocation tests in allergy diagnosis with birch pollen, timothy pollen and dog epithelium allergensClinical and Experimental Allergy, 1974
- Radioimmunosorbent assay of allergensJournal of Allergy and Clinical Immunology, 1972
- Studies in allergy: II. Serum serotonin levels in nonallergic, pretreatment, and posttreatment allergic human beings and in normal and sensitized guinea pigsJournal of Allergy, 1960
- THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONSAnnals of the New York Academy of Sciences, 1949
- On the Structure of a Catalyst SurfaceThe Journal of Chemical Physics, 1948