Age-Related Cataract in a Randomized Trial of Vitamins E and C in Men
- 8 November 2010
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Ophthalmology (1950)
- Vol. 128 (11), 1397-1405
- https://doi.org/10.1001/archophthalmol.2010.266
Abstract
Objective To test whether supplementation with alternate-day vitamin E or daily vitamin C affects the incidence of age-related cataract in a large cohort of men. Methods In a randomized, double-masked, placebo-controlled trial, 11 545 apparently healthy US male physicians 50 years or older without a diagnosis of cataract at baseline were randomly assigned to receive 400 IU of vitamin E or placebo on alternate days and 500 mg of vitamin C or placebo daily. Main Outcome Measure Incident cataract responsible for a reduction in best-corrected visual acuity to 20/30 or worse based on self-report confirmed by medical record review. Application to Clinical Practice Long-term use of vitamin E and C supplements has no appreciable effect on cataract. Results After 8 years of treatment and follow-up, 1174 incident cataracts were confirmed. There were 579 cataracts in the vitamin E–treated group and 595 in the vitamin E placebo group (hazard ratio, 0.99; 95% confidence interval, 0.88-1.11). For vitamin C, there were 593 cataracts in the treated group and 581 in the placebo group (hazard ratio, 1.02; 95% confidence interval, 0.91-1.14). Conclusion Long-term alternate-day use of 400 IU of vitamin E and daily use of 500 mg of vitamin C had no notable beneficial or harmful effect on the risk of cataract. Trial Registration clinicaltrials.gov Identifier:NCT00270647Keywords
This publication has 50 references indexed in Scilit:
- Vitamins E and C in the Prevention of Prostate and Total Cancer in MenJAMA, 2009
- Vitamins E and C in the Prevention of Cardiovascular Disease in MenJAMA, 2008
- Centrum Use and Progression of Age-Related Cataract in the Age-Related Eye Disease StudyOphthalmology, 2006
- Nutritional antioxidants and age-related cataract and maculopathyExperimental Eye Research, 2006
- Antioxidant Intake and Risk of Incident Age-related Nuclear Cataracts In the Beaver Dam Eye StudyAmerican Journal of Epidemiology, 1999
- Anticataract Action of Vitamin E: Its Estimation Using an in vitro Steroid Cataract ModelOphthalmic Research, 1996
- Cataract: relationship between nutrition and oxidation.Journal of the American College of Nutrition, 1993
- Final Report on the Aspirin Component of the Ongoing Physicians' Health StudyNew England Journal of Medicine, 1989
- Delay of uv-induced eye lens protein damage in guinea pigs by dietary ascorbateJournal of Free Radicals in Biology & Medicine, 1986
- In vitro effect of alpha-tocopherol on lysophosphatidylcholine-induced lens damageExperimental Eye Research, 1985