Respiration of Heart Muscle Slices from Rats in the Terminal Stage of Hemorrhagic Shock.

Abstract

The rate of O2 uptake of heart muscle slices from rats in the terminal stages of prolonged severe hemorrhagic shock is significantly less than normal in the absence of substrate. In the presence of Na pyruvate (0.02 M) the rate of O2 uptake is increased, but is still less than the normal rate. The course of the respiration in a 90 min. period, both in the presence and in the absence of substrate, is the same in normal heart slices and in heart tissue slices from rats in hemorrhagic shock.