Aggrecanase and Aggrecan Degradation in Osteoarthritis: A Review
- 1 December 2008
- journal article
- review article
- Published by SAGE Publications in Journal of International Medical Research
- Vol. 36 (6), 1149-1160
- https://doi.org/10.1177/147323000803600601
Abstract
Aggrecanase-mediated aggrecan degradation is a significant event in early-stage osteoarthritis (OA). Aggrecanases belonging to the 'A Disintegrin And Metalloproteinase with ThromboSpondin motifs' (ADAMTS) family of proteinases play a significant role in aggrecan depletion in osteoarthritic cartilage. There has been considerable interest in the possible role of these aggrecanases, especially ADAMTS-4 and ADAMTS-5, as therapeutic targets in OA. This article discusses recent data regarding ADAMTS-4 and ADAMTS-5 in OA, with emphasis on the relationship between aggrecanase and aggrecan degradation as well as the role of aggrecanase in OA.Keywords
This publication has 80 references indexed in Scilit:
- Distinguishing Aggrecan Loss from Aggrecan Proteolysis in ADAMTS-4 and ADAMTS-5 Single and Double Deficient MiceJournal of Biological Chemistry, 2007
- TNF-induced structural joint damage is mediated by IL-1Proceedings of the National Academy of Sciences, 2007
- TIMP-3 Inhibition of ADAMTS-4 (Aggrecanase-1) Is Modulated by Interactions between Aggrecan and the C-terminal Domain of ADAMTS-4Journal of Biological Chemistry, 2007
- Proteolytic Activities of Human ADAMTS-5Journal of Biological Chemistry, 2007
- Induction of increased cAMP levels in articular chondrocytes blocks matrix metalloproteinase–mediated cartilage degradation, but not aggrecanase‐mediated cartilage degradationArthritis & Rheumatism, 2007
- Synthesis and evaluation of aryl thioxothiazolidinone inhibitors of ADAMTS-5 (Aggrecanase-2)Bioorganic & Medicinal Chemistry Letters, 2007
- Increased collagen and aggrecan degradation with age in the joints of Timp3−/− miceArthritis & Rheumatism, 2007
- A microplate assay for the screening of ADAMTS-4 inhibitorsMatrix Biology, 2006
- Intracranial Injury Acutely Induces the Expression of the Secreted Isoform of the CNS-Specific Hyaluronan-Binding Protein BEHAB/BrevicanExperimental Neurology, 1999
- Characterization of Aggrecan Retained and Lost from the Extracellular Matrix of Articular CartilageJournal of Biological Chemistry, 1998