HLA antigens in South India: II. Selected caste groups of Tamil Nadu
- 1 September 1987
- journal article
- research article
- Published by Wiley in Tissue Antigens
- Vol. 30 (3), 113-118
- https://doi.org/10.1111/j.1399-0039.1987.tb01606.x
Abstract
HLA-A, B antigen and haplotype frequencies were studied in four different caste groups of Tamil Nadu living in Madurai. A total number of 101 Nadars, 36 Kallars, 54 Iyers and 57 Telugu-speaking Naidus were studied. HLA A3 and B15 were significantly higher in Nadars; A10 and B8 in Kallars and Aw19, B12 and B35 in Iyers. HLA A-B haplotypes A10-B7, A28-B17 and A24-B- were characteristic of Nadars; A10-B8 and A1-B-, Kallars; Aw19-B12 and A1-B15, Iyers and A2-B-, Naidus. Negative linkage disequilibria for Aw19-B7, A28-B15 and A9-B51 were significant in Nadars; A1-B5, A1-B12 and Aw19-B- in Iyers and A2-B17 in Naidus. Heterogeneity chi-square based on antigen frequency and genetic distance also suggest the heterogeneous nature of the population of South India. Will these caste groups with such diverse haplotypic combinations differ from one another in their immune response and susceptibility to a given epidemic or infection?This publication has 6 references indexed in Scilit:
- Distribution of HLA antigens in a sample of the North Indian Hindu populationTissue Antigens, 1986
- Study of the HLA gene and antigen frequency from a Saudi Arabian hospitalTissue Antigens, 1985
- HLA antigens in South India: I. Major groups of Tamil NaduTissue Antigens, 1984
- Population Analysis on the Basis of Deduced Haplotypes from Random FamiliesPublished by Springer Nature ,1984
- The Major Histocompatibility Complex in ManScience, 1981