THE EFFECT OF OESTRIN ON DEVELOPMENT OF THE OVARY IN IMMATURE FEMALE RATS*

Abstract

Injection of follicular hormone prevented the ovaries of immature rats from reaching full growth and development as indicated by the weight of the glands,[long dash]an effect not readily detected unless the injections are continued beyond sexual maturity. The weights of the pituitary, thymus, thyroid and adrenals remain practically unchanged. Physiologically, the pituitaries of rats receiving oestrin were less potent in inducing sexual precocity in immature female rats; thus, by its influence on the hypophysis, oestrin inhibits the development of the ovary.