Enhanced percutaneous penetration with 1-dodecylazacycloheptan-2-one

Abstract

1-Dodecylazacycloheptan-2-one (Azone) is a new agent that enhances the percutaneous absorption of a number of different chemicals. The enhancement of penetration of clindamycin phosphate, erythromycin base, fusidate sodium, fluorouracil, desonide, amcinonide and triamcinolone acetonide is discussed. For this purpose 1-dodecylazacycloheptan-2-one can be used in concentrations as low as 1%. It is colorless, relatively odorless, nontoxic and can be applied neat to human skin without any irritation.