Autoradiographic Investigations of 14G-labelled Thalidomide and Glutethimide in Pregnant Mice

Abstract

Summary The distribution in pregnant mice of ¹⁴C-labelled thalidomide and glutethimide was investigated autoradiographically. After administration of ¹⁴C-thalidomide the radioactivity was found to penetrate through the placenta and to be distributed very evenly in both mother and fetuses. After administration of ¹⁴C-glutethimide a specific accumulation was seen in fat, brain, myocardium, blood vessel walls and mammary glands.