Eine chiral ökonomische Totalsynthese von natürlichen und unnatürlichen Prostaglandinen
- 1 January 1975
- journal article
- abstracts
- Published by Wiley in Helvetica Chimica Acta
- Vol. 58 (2), 564-584
- https://doi.org/10.1002/hlca.19750580228
Abstract
Using a meso‐compound which is asymmetrically substituted with a chiral moiety as an intermediate, prostaglandins have been synthesized. Since the undesired enantiomer is readily recycled, this approach leads to a synthesis with high chiral efficiency. In addition it is possible to prepare both enantiomeric configurations of prostaglandins by simply altering the sequence of reactions. This concept should be generally useful in the synthesis of optically active molecules.This publication has 18 references indexed in Scilit:
- Asymmetric synthesis of prostaglandin intermediatesJournal of the American Chemical Society, 1973
- Novel synthesis of prostaglandin F2.alpha.Journal of the American Chemical Society, 1973
- The Total Synthesis of ProstaglandinsPublished by Wiley ,1973
- Total syntheses of prostanoidsChemical Society Reviews, 1973
- Stereospecific total synthesis of the natural and racemic prostaglandins of the E and F seriesJournal of the American Chemical Society, 1972
- Methoxymethylation of thallous cyclopentadienide. Simplified preparation of a key intermediate for the synthesis of prostaglandinsJournal of the American Chemical Society, 1971
- Stereo-controlled synthesis of dl-prostaglandins F2.alpha. and E2Journal of the American Chemical Society, 1969
- Synthesis of prostaglandin F1.alpha. and related substancesJournal of the American Chemical Society, 1969
- Total synthesis of natural (levo) and enantiomeric (dextro) forms of prostaglandin E1Journal of the American Chemical Society, 1969
- Total synthesis of prostaglandins. Synthesis of the pure dl-E1, -F(sub 1.alpha.), -F(sub 1.beta.), -A1, and -B1 hormonesJournal of the American Chemical Society, 1968