REFUTATION OF THE GENERAL SINGLE-LOCUS MODEL FOR THE ETIOLOGY OF SCHIZOPHRENIA
- 1 January 1982
- journal article
- research article
- Vol. 34 (4), 630-649
Abstract
All published studies on the familial incidence of schizophrenia appropriate for testing the applicability of the general single-locus 2-allele model are examined under the assumption of a unitary etiology for all schizophrenia. The single major locus model is inadequate to predict the incidence in 4 classes of relatives of schizophrenic probands (parents, siblings, monozygotic and dizygotic cotwins). The observed proportion of affected offspring from dual matings differ significantly from the model''s prediction. The lack of an overall fit between the published familial distributions and the monogenic model suggests that a single major locus is insufficient for the etiology of schizophrenia. Further efforts in examining multifactorial models, mixed models and other transmission models may be fruitful.This publication has 45 references indexed in Scilit:
- The offspring of schizophrenic parents in a North Swedish isolateClinical Genetics, 1980
- Recurrence risks in schizophrenia: Are they model dependent?Behavior Genetics, 1979
- Do the Partners of Dizygotic Schizophrenic Twins Run a Greater Risk of Schizophrenia than Ordinary Siblings?Human Heredity, 1979
- The value of dual mating data in estimating genetic parametersAnnals of Human Genetics, 1978
- Testing a single dominant gene theory without an accepted criterion variableAnnals of Human Genetics, 1978
- Estimating the Parameters of the Incompletely Penetrant Single Locus Model Using Multiple PopulationsHuman Heredity, 1977
- Frequency in relatives for an all‐or‐none traitAnnals of Human Genetics, 1971
- Schizophrenia: Evidence for the major gene hypothesisBehavior Genetics, 1970
- The inheritance of liability to diseases with variable age of onset, with particular reference to diabetes mellitusAnnals of Human Genetics, 1967
- THE CALCULATION OF MORBID RISK IN PARENTS OF INDEX CASES, AS APPLIED TO A FAMILY SAMPLE OF SCHIZOPHRENICSHuman Heredity, 1954