The dual role of IRF8 in cancer immunosurveillance
Open Access
- 1 August 2013
- journal article
- Published by Taylor & Francis in OncoImmunology
- Vol. 2 (8), e25476
- https://doi.org/10.4161/onci.25476
Abstract
For a long time, the transcription factor interferon-regulatory factor 8 (IRF8) has been recognized as a masterpiece for the development of myeloid cells, and its role as a central regulator of immune responses has now been clarified. IRF8 is also critical for tumor progression, suggesting its fundamental relevance in multiple aspects of cancer immunosurveillance.Keywords
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