The Potentiating Effect of Alcohol on Thiopental Induced Sleep.

Abstract

Thiopental in subanesthetic doses caused a significant decrease in the reaction time of mice. Alcohol in doses even very near the hypnotic level did not significantly change the reaction time. When the 2 drugs were given simultaneously, the reaction time was still not significantly changed. The sleeping times of mice, dogs and rabbits given both thiopental and alcohol were significantly longer than the sleeping times when either of the 2 drugs alone were given.