How Much hydration is necessary for the stabilisation of DNA-duplex?
- 11 September 1993
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 21 (18), 4246-4252
- https://doi.org/10.1093/nar/21.18.4246
Abstract
A combination of NOESY and ROESY experiments show that the higher stabilities (T m ) of phenazlne tethered matched (2) and G-A mismatched (4) DNA duplexes are due to the decrease of the exchange-rate (I.e. Increase of the life-time) of the Imlno-protons and the reduced water activity In their minor grooves compared to their non-tethered counterparts (1) and (3).Keywords
This publication has 9 references indexed in Scilit:
- Structural studies of the 5′-phenazinium-tethered matched and G-A-mismatched DNA duplexes by NMR spectroscopyJournal of Biochemical and Biophysical Methods, 1993
- Crystal structure of a B-DNA dodecamer containing inosine, d(CGCIAATTCGCG), at 2.4 Å resolution and its comparison with other B-DNA dodecamersNucleic Acids Research, 1992
- Alternative structures for alternating poly(dA-dT) tracts: the structure of the B-DNA decamer C-G-A-T-A-T-A-T-C-G.1992
- Molecular structure of the B-DNA dodecamer d(CGCAAATTTGCG)2 An examination of propeller twist and minor-groove water structure at 2·2ÅresolutionJournal of Molecular Biology, 1992
- NMR observation of individual molecules of hydration water bound to DNA duplexes: direct evidence for a spine of hydration water present in aqueous solutionNucleic Acids Research, 1992
- Protein hydration studied with homonuclear 3D1H NMR experimentsJournal of Biomolecular NMR, 1991
- Crystal and molecular structure of a DNA fragment: d(CGTGAATTCACG)Biochemistry, 1991
- Sequence-specific intercalating agents: intercalation at specific sequences on duplex DNA via major groove recognition by oligonucleotide-intercalator conjugates.Proceedings of the National Academy of Sciences, 1989
- Base pair opening dynamics of a 2-aminopurine substituted Eco RI restricion sequence and its unsubstituted counterpart in oligonucleotidesNucleic Acids Research, 1987