Dactinomycin: Relative Resistance of Green Monkey Kidney Cell Cultures to its Action.
- 1 May 1967
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 125 (1), 65-67
- https://doi.org/10.3181/00379727-125-32014
Abstract
The action of dactinomycin on cellular RNA synthesis and vaccinia virus multiplication in HeLa, mouse embryo (ME), African green monkey kidney (GMK) cells in culture were compared. Approximately a 10-100 fold higher concentration of dactinomycin was required in GMK cells as compared with HeLa cells and ME to equivalently suppress the cellular RNA synthesis and vaccinia virus multiplication. Also, dactinomycin was approximately 100-fold less toxic for GMK. The higher concentrations of dactinomycin required to inhibit GMK as compared with HeLa cells is probably due to a lower uptake of the antibiotic by the GMK cells.This publication has 5 references indexed in Scilit:
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