Slow Joining of Newly Replicated DNA Chains in DNA Polymerase I-Deficient Escherichia coli Mutants
- 1 December 1971
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 68 (12), 2954-2957
- https://doi.org/10.1073/pnas.68.12.2954
Abstract
In Escherichia coli mutants deficient in DNA polymerase I, newly replicated short DNA is joined at about 10% of the rate in the wild-type strains. It is postulated that DNA polymerase I normally functions in filling gaps between the nascent short segments synthesized by the replication complex. Possible implications of the finding are discussed in relation to other abnormal properties of these mutants.Keywords
This publication has 31 references indexed in Scilit:
- DNA Polymerase Required for Rapid Repair of X-ray—Induced DNA Strand Breaks in vivoScience, 1971
- Mechanism of DNA ReplicationNature, 1971
- DNA Polymerase IINature, 1970
- A possible function of DNA polymerase in chromosome replicationBiochemical and Biophysical Research Communications, 1970
- Increased Frequency of Deletions in DNA Polymerase Mutants of Escherichia coliNature, 1970
- Excision-repair Properties of an Escherichia coli Mutant deficient in DNA PolymeraseNature, 1970
- Repair deficiency in a bacterial mutant defective in DNA polymeraseBiochemical and Biophysical Research Communications, 1970
- Genetic Analysis of an E. coli Strain with a Mutation affecting DNA PolymeraseNature, 1969
- Enzymic synthesis of DNA: XXXIII. Hydrolysis of a 5′-triphosphate-terminated polynucleotide in the active center of DNA polymeraseJournal of Molecular Biology, 1969
- Active Center of DNA PolymeraseScience, 1969