The authors report experiences of their own and of their colleagues at the Mayo Clinic in 45 cases of osteitis pubis, in the hope of removing this condition from the narrow vision of the specialist who sees but an occasional case and correlating it with the broader aspects of the problem. They emphasize that it concerns not only the urologist and other specialists—orthopedist, radiologist, gynecologic surgeon, and internist—but also the general practitioner. Since cultures of material obtained from the bone at operation or by biopsy in 5 cases were sterile, they believe that the underlying difficulty is venous congestion secondary to inflammation in the adjacent urinary tract. Treatment was aimed at clearing up the urinary infection and relieving symptoms by local measures. In 5 cases symptoms were relieved by surgery.