Vancomycin and Oxacillin Synergy for Methicillin-Resistant Staphylococci
- 1 May 2000
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 44 (5), 1394-1396
- https://doi.org/10.1128/aac.44.5.1394-1396.2000
Abstract
An increase in oxacillin activity was observed against methicillin-resistant coagulase-negative staphylococci (MRCNS) and methicillin-resistant Staphylococcus aureus (MRSA) in the presence of a sub-MIC of vancomycin. Vancomycin and oxacillin were synergistic against 14 of 21 strains of MRCNS and MRSA. A pattern of enhanced killing was also supported by time-kill studies. These results suggest that combinations of sub-MICs of vancomycin and oxacillin may have therapeutic benefits against methicillin-resistant staphylococci.Keywords
This publication has 13 references indexed in Scilit:
- The Development of Vancomycin Resistance in a Patient with Methicillin-ResistantStaphylococcus aureusInfectionNew England Journal of Medicine, 1999
- Decreased Susceptibilities to Teicoplanin and Vancomycin among Coagulase-Negative Methicillin-Resistant Clinical Isolates of StaphylococciAntimicrobial Agents and Chemotherapy, 1998
- Update: Staphylococcus aureus with reduced susceptibility to vancomycin--United States, 1997.1997
- Staphylococcus aureus with reduced susceptibility to vancomycin--United States, 1997.1997
- Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibilityJournal of Antimicrobial Chemotherapy, 1997
- Activities of levofloxacin, ofloxacin, and ciprofloxacin, alone and in combination with amikacin, against acinetobacters as determined by checkerboard and time-kill studiesAntimicrobial Agents and Chemotherapy, 1997
- The in-vitro antibacterial activity of a combination of cefpirome or cefoperazone with vancomycin against enterococci and Staphylococcus aureusJournal of Antimicrobial Chemotherapy, 1992
- In vitro selection of resistance to vancomycin in bloodstream isolates ofStaphylococcus haemolyticus andStaphylococcus epidermidisEuropean Journal of Clinical Microbiology & Infectious Diseases, 1991
- Selection for Vancomycin Resistance in Clinical Isolates of Staphylococcus haemolyticusThe Journal of Infectious Diseases, 1990
- Emergence of Vancomycin Resistance in Coagulase-Negative StaphylococciNew England Journal of Medicine, 1987