Nephrotic Syndrome Caused by Probenecid

Abstract

THE nephrotic syndrome has been reported to occur in the course of therapy with a number of drugs including trimethadione,^{1 , 2} paramethadione,³ mercurial diuretics,⁴ tolbutamide⁵ and perchlorate,⁶ as well as in association with sensitivity to poison oak⁷ and bee sting.⁸ In the case reported below, the nephrotic syndrome appeared to be the result of a reaction to probenecid.¶ Although proteinuria and renal failure are known to occur in the course of chronic gout, the nephrotic syndrome has not heretofore been reported as a result of gouty nephritis or in association with probenecid therapy.Case ReportA 52-year-old man was first seen . . .