Experimental production of focal neurologic deficit by systemic hyponatremia

Abstract

Hyponatremia, induced in dogs that had previously had ligation of the left middle cerebral artery and were allowed to make complete neurologic recovery, caused a right hemi-paresis. This focal neurologic deficit could be immediately and dramatically abolished by infusion of Na ions. It is suggested that Scholz''s theory of pathoclisis in the central nervous system does indeed have both a biochemical and vascular basis. In view of the fact that so many patients with the signs and symptons of cerbrovascular insufficiency receive saluretic drugs, the possible role of hyponatremia in the pathogenesis of such signs and symptoms must be considered.