A Method for Producing Chronic Cardiac Failure in Dogs.

Abstract

A form of progressive, chronic "right-sided" cardiac failure was produced in dogs by tricuspid valve avulsion and pulmonary artery stenosis. Dogs so treated developed congestive failure with elevated auricular pressure and distended veins, decreased work tolerance, hepatomegaly, ascites, tachycardia at rest, and a relatively fixed heart rate during exercise. Studies of the hearts in the heart-lung prepn. indicate that cardiac insufficiency was present.