A Succinct Asymmetric Synthesis of (2S,3R)-2-Methyl-3-aminopentanoic Acid Hydrochloride

Abstract

The highly stereoselective conjugate addition of lithium (R)-(α-methylbenzyl)benzylamide (R)-2 to tert-butyl (E)-2-methyl-2-pentenoate 3 affords a straightforward synthesis of (2S,3R)-2-methyl-3-aminopentanoic acid 1 as its hydrochloride salt 5.