Metabolism of Chloroform—I. The Metabolism of [14C] Chloroform by Different Species
- 1 January 1974
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 4 (3), 151-163
- https://doi.org/10.3109/00498257409049355
Abstract
1. The metabolism of [14C]chloroform by the mouse, rat and monkey has been investigated. A pronounced species variation was observed. 2. In all three strains of mice examined about 80% of a dose of 60 mg/kg 14CHCl3 was converted to 14CO2. In the rat about 60% conversion occurred whilst only 20% conversion occurred in the squirrel monkey. 3. [14C]Urea was present in the urine of both rat and mouse, together with at least two other metabolites. 4. Whole-body autoradiography was carried out on rat and monkey. 5. 14CHCl3 was detected in monkey bile. 6. Blood levels of radioactivity were determined after oral dosage of 14CHCl3 to mice and monkeys.Keywords
This publication has 8 references indexed in Scilit:
- Metabolism of Chloroform—II. A Sex Difference in the Metabolism of [14C]Chloroform in MiceXenobiotica, 1974
- Metabolism and biliary excretion of the lipophilic drug molecules, imipramine and desmethylimipramine in the rat—II: Uptake into bile micellesBiochemical Pharmacology, 1970
- Biliary excretion of foreign compounds. Biphenyl, stilboestrol and phenolphthalein in the rat: molecular weight, polarity and metabolism as factors in biliary excretionBiochemical Journal, 1967
- Biliary excretion of foreign compounds. Benzene and its derivatives in the ratBiochemical Journal, 1967
- A simple method for the determination of the specific activity of carbon dioxide in bloodAnalytical Biochemistry, 1966
- Metabolism of volatile anasthetics—IBiochemical Pharmacology, 1964
- Blood and Tissue Levels of Ether, Chloroform, Halothane and Methoxyflurane in DogsAnesthesiology, 1962
- Adaptation of Orbital Bleeding Technic to Rapid Serial Blood StudiesExperimental Biology and Medicine, 1960