Increased Alzheimer pathology in Parkinson's disease related to antimuscarinic drugs
- 25 July 2003
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 54 (2), 235-238
- https://doi.org/10.1002/ana.10639
Abstract
The hypothesis that blockade of muscarinic receptors is associated with increased Alzheimer-type pathology was investigated in Parkinson's disease. Amyloid plaque densities were more than 2.5-fold higher in cases treated with antimuscarinic medication in the long term compared with untreated or short-term treated cases (p = 0.005 and 0.00005, respectively). Neurofibrillary tangle densities were also highest in chronic compared with untreated or acute-treated groups (p = 0.02 and 0.05, respectively). The findings, if replicated, have potential implications for the use of anticholinergic medication in elderly Parkinson's disease patients. Ann Neurol 2003Keywords
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